HC: Kyle Shanahan
OC: Chris Foerster & Bobby Slowik
DC: DeMeco Ryans
Depth Chart:
QB: Jimmy Garoppolo
Trey Lance, Nate Sudfeld, Brock Purdy (R)
RB: Elijah Mitchell
Tyrion Davis-Price (R), Jeff Wilson, JaMycal Hasty, Trey Sermon, Jordan Mason (R)
FB: Kyle Juszczyk
Josh Hokit
WR: Deebo Samuel, Brandon Aiyuk
Jauan Jennings, Ray-Ray McCloud, Marcus Johnson, Danny Gray (R), Malik Turner, Austin Mack, KeeSean Johnson, Connor Wedington, Taysir Mack (R), Tay Martin (R)
TE: George Kittle
Ross Dwelley, Charlie Woerner, Tanner Hudson, Jordan Matthews, Garrett Walston (R)
Redraft Take: We need to know if it’s Trey Lance or Jimmy Garappolo to accurately assess this team’s fantasy potential. Continue taking George Kittle, Deebo Samuel, Elijah Mitchell and Brandon Aiyuk for now.
2022 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 2.29 | 61 | DE | Drake Jackson | SF | USC |
| 3.29 | 93 | RB | Tyrion Davis-Price | SF | LSU |
| 3.41 | 105 | WR | Danny Gray | SF | SMU |
| 4.29 | 134 | OT | Spencer Burford | SF | UTSA |
| 5.29 | 172 | CB | Samuel Womack | SF | Toledo |
| 6.08 | 187 | OT | Nick Zakelj | SF | Fordham |
| 6.41 | 220 | DT | Kalia Davis | SF | UCF |
| 6.42 | 221 | CB | Tariq Castro-Fields | SF | Penn State |
| 7.41 | 262 | QB | Brock Purdy | SF | Iowa State |
2021 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.03 | 3 | QB3 | Trey Lance | SF | North Dakota State |
| 2.16 | 48 | OG3 | Aaron Banks | SF | Notre Dame |
| 3.24 | 88 | RB4 | Trey Sermon | SF | Ohio State |
| 3.38 | 102 | CB15 | Ambry Thomas | SF | Michigan |
| 5.11 | 155 | OG8 | Jaylon Moore | SF | Western Michigan |
| 5.28 | 172 | CB26 | Deommodore Lenoir | SF | Oregon |
| 5.36 | 180 | S14 | Talanoa Hufanga | SF | USC |
| 6.10 | 194 | RB10 | Elijah Mitchell | SF | Louisiana |
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 1.14 | 14 | DT | Javon Kinlaw | South Carolina |
| 1.25 | 25 | WR | Brandon Aiyuk | Arizona State |
| 5.07 | 153 | T | Colton McKivitz | West Virginia |
| 6.11 | 190 | TE | Charlie Woerner | Georgia |
| 7.03 | 217 | WR | Jauan Jennings | Tennessee |