HC: Kyle Shanahan
OC: Chris Foerster & Bobby Slowik
DC: DeMeco Ryans
Depth Chart:
QB: Trey Lance
Jimmy Garoppolo, Nate Sudfeld, Brock Purdy (R)
RB: Elijah Mitchell
Tyrion Davis-Price (R), Jeff Wilson, JaMycal Hasty, Trey Sermon, Jordan Mason (R)
FB: Kyle Juszczyk
Josh Hokit
WR: Deebo Samuel, Brandon Aiyuk
Jauan Jennings, Ray-Ray McCloud, Marcus Johnson, Danny Gray (R), Malik Turner, Austin Mack, KeeSean Johnson, Connor Wedington, Taysir Mack (R), Tay Martin (R)
TE: George Kittle
Ross Dwelley, Charlie Woerner, Tanner Hudson, Jordan Matthews, Garrett Walston (R)
Redraft Take: It finally sounds like Trey Lance is getting the starting job, as Jimmy G trade rumors heat up this summer. Continue taking George Kittle, Deebo Samuel, Elijah Mitchell and Brandon Aiyuk for now at ADP. I love Lance as my QB2 in Superflex and am open to him being a top 10/12 QB1 in standard leagues.
2022 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 2.29 | 61 | DE | Drake Jackson | SF | USC |
| 3.29 | 93 | RB | Tyrion Davis-Price | SF | LSU |
| 3.41 | 105 | WR | Danny Gray | SF | SMU |
| 4.29 | 134 | OT | Spencer Burford | SF | UTSA |
| 5.29 | 172 | CB | Samuel Womack | SF | Toledo |
| 6.08 | 187 | OT | Nick Zakelj | SF | Fordham |
| 6.41 | 220 | DT | Kalia Davis | SF | UCF |
| 6.42 | 221 | CB | Tariq Castro-Fields | SF | Penn State |
| 7.41 | 262 | QB | Brock Purdy | SF | Iowa State |
2021 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.03 | 3 | QB3 | Trey Lance | SF | North Dakota State |
| 2.16 | 48 | OG3 | Aaron Banks | SF | Notre Dame |
| 3.24 | 88 | RB4 | Trey Sermon | SF | Ohio State |
| 3.38 | 102 | CB15 | Ambry Thomas | SF | Michigan |
| 5.11 | 155 | OG8 | Jaylon Moore | SF | Western Michigan |
| 5.28 | 172 | CB26 | Deommodore Lenoir | SF | Oregon |
| 5.36 | 180 | S14 | Talanoa Hufanga | SF | USC |
| 6.10 | 194 | RB10 | Elijah Mitchell | SF | Louisiana |
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 1.14 | 14 | DT | Javon Kinlaw | South Carolina |
| 1.25 | 25 | WR | Brandon Aiyuk | Arizona State |
| 5.07 | 153 | T | Colton McKivitz | West Virginia |
| 6.11 | 190 | TE | Charlie Woerner | Georgia |
| 7.03 | 217 | WR | Jauan Jennings | Tennessee |