HC: Kyle Shanahan
OC: Mike McDaniel
DC: DeMeco Ryans
Depth Chart: (blue = drafted, green = udfa)
QBs: Jimmy Garoppolo – Trey Lance (1st)
Nick Mullens – Josh Rosen – Josh Johnson – Nate Sudfeld
RBs: Raheem Mostert – Wayne Gallman – Trey Sermon (3rd)
Jeff Wilson (IR) – JaMycal Hasty – Josh Hokit – Elijah Mitchell (6th)
FB: Kyle Juszcyzk
Daniel Helm
WRs: Deebo Samuel – Brandon Aiyuk
Mohamed Sanu – Richie James – Jalen Hurd – Trent Sherfield – Jauan Jennings – River Cracraft – Kevin White – Austin Proehl – Travis Benjamin – Austin Watkins Jr.
TEs: George Kittle
Charlie Woerner – Ross Dwelley – Josh Pederson
2021 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.03 | 3 | QB3 | Trey Lance | SF | North Dakota State |
| 2.16 | 48 | OG3 | Aaron Banks | SF | Notre Dame |
| 3.24 | 88 | RB4 | Trey Sermon | SF | Ohio State |
| 3.38 | 102 | CB15 | Ambry Thomas | SF | Michigan |
| 5.11 | 155 | OG8 | Jaylon Moore | SF | Western Michigan |
| 5.28 | 172 | CB26 | Deommodore Lenoir | SF | Oregon |
| 5.36 | 180 | S14 | Talanoa Hufanga | SF | USC |
| 6.10 | 194 | RB10 | Elijah Mitchell | SF | Louisiana |
2021 Notable Additions:
- C Alex Mack
- LB Samson Ebukam
- DT DJ Jones
- CB K’Waun Williams
- RB Wayne Gallman
2021 Notable Departures:
- WR Kendrick Bourne
- DE Kerry Hyder
- QB CJ Beathard
- CB Ahkello Witherspoon
- DE Solomon Thomas
- RB Tevin Coleman
- RB Jerick McKinnon
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 1.14 | 14 | DT | Javon Kinlaw | South Carolina |
| 1.25 | 25 | WR | Brandon Aiyuk | Arizona State |
| 5.07 | 153 | T | Colton McKivitz | West Virginia |
| 6.11 | 190 | TE | Charlie Woerner | Georgia |
| 7.03 | 217 | WR | Jauan Jennings | Tennessee |
Helpful Links:
Total Offensive Plays Per Game
Total Offensive Plays Per Season (filter by Ply)