% Rush = % of total team red zone rushing attempts taken by this player
| Player | Tm | Att | Yds | TD | %Rush | |
| 1 | Jamaal Williams | DET | 28 | 24 | 14 | 84.80% |
| 2 | Jalen Hurts | PHI | 20 | 12 | 9 | 48.80% |
| 3 | Ezekiel Elliott | DAL | 16 | 17 | 9 | 69.60% |
| 4 | Dalvin Cook | MIN | 15 | 12 | 5 | 60.00% |
| 5 | Derrick Henry | TEN | 15 | 24 | 10 | 88.20% |
| 6 | Joe Mixon | CIN | 14 | 10 | 5 | 63.60% |
| 7 | Saquon Barkley | NYG | 14 | 24 | 7 | 58.30% |
| 8 | Nick Chubb | CLE | 12 | 12 | 6 | 63.20% |
| 9 | Miles Sanders | PHI | 11 | 17 | 5 | 26.80% |
| 10 | Josh Jacobs | LVR | 11 | 8 | 5 | 91.70% |
| 11 | Josh Allen | BUF | 11 | 7 | 4 | 61.10% |
| 12 | Travis Etienne | JAX | 10 | 5 | 2 | 43.50% |
| 13 | Christian McCaffrey | 2TM | 10 | 5 | 5 | |
| 14 | AJ Dillon | GNB | 10 | 10 | 4 | 62.50% |
| 15 | Justin Fields | CHI | 10 | 19 | 5 | 50.00% |
| 16 | Najee Harris | PIT | 9 | 6 | 3 | 37.50% |
| 17 | Kenneth Walker | SEA | 9 | -3 | 1 | 100.00% |
| 18 | Austin Ekeler | LAC | 8 | 9 | 6 | 53.30% |
| 19 | Leonard Fournette | TAM | 8 | 7 | 3 | 61.50% |
| 20 | Jonathan Taylor | IND | 8 | 8 | 3 | 50.00% |
| 21 | Antonio Gibson | WAS | 8 | -5 | 3 | 47.10% |
| 22 | Jeff Wilson | 2TM | 8 | 2 | 3 | |
| 23 | Cam Akers | LAR | 8 | 8 | 5 | 57.10% |
| 24 | Isiah Pacheco | KAN | 7 | 8 | 3 | 30.40% |
| 25 | Rhamondre Stevenson | NWE | 7 | 3 | 2 | 58.30% |
| 26 | Devin Singletary | BUF | 7 | 1 | 2 | 38.90% |
| 27 | D’Onta Foreman | CAR | 7 | 8 | 3 | 50.00% |
| 28 | Dameon Pierce | HOU | 7 | -2 | 3 | 53.80% |
| 29 | Daniel Jones | NYG | 7 | -4 | 3 | 29.20% |
| 30 | Joe Burrow | CIN | 7 | 8 | 4 | 31.80% |
| 31 | Tyler Allgeier | ATL | 6 | 4 | 1 | 33.30% |
| 32 | James Conner | ARI | 6 | 8 | 4 | 37.50% |
| 33 | Tony Pollard | DAL | 6 | 4 | 2 | 26.10% |
| 34 | Kenneth Gainwell | PHI | 6 | 13 | 3 | 14.60% |
| 35 | Latavius Murray | 2TM | 6 | 10 | 5 | |
| 36 | Melvin Gordon | DEN | 6 | 2 | 2 | 40.00% |
| 37 | Trevor Lawrence | JAX | 6 | 7 | 5 | 26.10% |
| 38 | Khalil Herbert | CHI | 6 | 2 | 2 | 30.00% |
| 39 | Kenny Pickett | PIT | 6 | 5 | 3 | 25.00% |
| 40 | Brian Robinson | WAS | 5 | 4 | 2 | 29.40% |
| 41 | Cordarrelle Patterson | ATL | 5 | 11 | 4 | 27.80% |
| 42 | Jerick McKinnon | KAN | 5 | 1 | 0 | 21.70% |
| 43 | Kareem Hunt | CLE | 4 | 6 | 2 | 21.10% |
| 44 | D’Andre Swift | DET | 4 | 2 | 2 | 12.10% |
| 45 | James Robinson | 2TM | 4 | 1 | 0 | |
| 46 | Lamar Jackson | BAL | 4 | 3 | 1 | 25.00% |
| 47 | Breece Hall | NYJ | 4 | -2 | 1 | 28.60% |
| 48 | Alvin Kamara | NOR | 4 | 8 | 2 | 36.40% |
| 49 | Marcus Mariota | ATL | 4 | 4 | 3 | 22.20% |
| 50 | J.K. Dobbins | BAL | 4 | 8 | 2 | 25.00% |
| 51 | Kyler Murray | ARI | 4 | 5 | 2 | 25.00% |
| 52 | David Montgomery | CHI | 3 | 3 | 2 | 15.00% |
| 53 | Taysom Hill | NOR | 3 | 2 | 2 | 27.30% |
| 54 | Alexander Mattison | MIN | 3 | -3 | 2 | 12.00% |
| 55 | Raheem Mostert | MIA | 3 | 2 | 1 | 25.00% |
| 56 | Michael Carter | NYJ | 3 | 4 | 2 | 21.40% |
| 57 | Joshua Kelley | LAC | 3 | 4 | 1 | 20.00% |
| 58 | Kenyan Drake | BAL | 3 | 8 | 3 | 18.80% |
| 59 | Zack Moss | IND | 3 | -3 | 0 | 18.80% |
| 60 | Patrick Mahomes | KAN | 3 | 6 | 2 | 13.00% |
| 61 | Rachaad White | TAM | 3 | 2 | 1 | 23.10% |
| 62 | Aaron Jones | GNB | 2 | 2 | 0 | 12.50% |
| 63 | Gus Edwards | BAL | 2 | 2 | 2 | 12.50% |
| 64 | Elijah Mitchell | SFO | 2 | 0 | 0 | 6.50% |
| 65 | Damien Harris | NWE | 2 | 4 | 2 | 16.70% |
| 66 | Jacoby Brissett | CLE | 2 | 7 | 2 | 10.50% |
| 67 | Jaylen Warren | PIT | 2 | 3 | 1 | 8.30% |
| 68 | Caleb Huntley | ATL | 1 | 2 | 0 | 5.60% |
| 69 | Chuba Hubbard | CAR | 1 | 2 | 1 | 7.10% |
| 70 | Eno Benjamin | 2TM | 1 | 2 | 0 | |
| 71 | Tyler Huntley | BAL | 1 | 2 | 1 | 6.30% |
| 72 | Samaje Perine | CIN | 0 | 0 | 0 | 0.00% |
| 73 | James Cook | BUF | 0 | 0 | 0 | 0.00% |