HC: Mike Tomlin
OC: Matt Canada
DC: Teryl Austin
Depth Chart:
QB: Mitchell Trubisky
Kenny Pickett (R), Mason Rudolph, Chris Oladokun (R)
RB: Najee Harris
Benny Snell Jr., Anthony McFarland, Trey Edmunds, Mataeo Durant (R), Jaylen Warren R)
FB: Derek Watt
WR: Diontae Johnson, Chase Claypool, George Pickens (R)
Calvin Austin III (R), Miles Boykin, Anthony Miller, Cody White, Rico Bussey, Gunner Olszewski, Tyler Vaughns, Steven Sims
TE: Pat Freiermuth
Zach Gentry, Kevin Rader, Connor Heyward (R), Jace Sternberger
2022 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.20 | 20 | QB | Kenny Pickett | PIT | Pittsburgh |
| 2.20 | 52 | WR | George Pickens | PIT | Georgia |
| 3.20 | 84 | DE | DeMarvin Leal | PIT | Texas A&M |
| 4.33 | 138 | WR | Calvin Austin | PIT | Memphis |
| 6.29 | 208 | FB | Connor Heyward | PIT | Michigan State |
| 7.04 | 225 | LB | Mark Robinson | PIT | Ole Miss |
| 7.20 | 241 | QB | Chris Oladokun | PIT | South Dakota State |
2021 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.24 | 24 | RB1 | Najee Harris | PIT | Alabama |
| 2.23 | 55 | TE2 | Pat Freiermuth | PIT | Penn State |
| 3.23 | 87 | OG5 | Kendrick Green | PIT | Illinois |
| 4.23 | 128 | OT15 | Dan Moore | PIT | Texas A&M |
| 4.35 | 140 | LB13 | Buddy Johnson | PIT | Texas A&M |
| 5.12 | 156 | DT10 | Isaiahh Loudermilk | PIT | Wisconsin |
| 6.32 | 216 | DE28 | Quincy Roche | PIT | Miami OH |
| 7.17 | 245 | CB37 | Tre Norwood | PIT | Oklahoma |
| 7.26 | 254 | P1 | Pressley Harvin III | PIT | Georgia Tech |
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 2.17 | 49 | WR | Chase Claypool | Notre Dame |
| 3.38 | 102 | EDGE | Alex Highsmith | Charlotte |
| 4.18 | 124 | RB | Anthony McFarland | Maryland |
| 4.29 | 135 | G | Kevin Dotson | Louisiana Lafayette |
| 6.19 | 198 | S | Antoine Brooks Jr. | Maryland |
| 7.18 | 232 | DT | Carlos Davis | Nebraska |