HC: Josh McDaniels
OC: Mick Lombardi
DC: Patrick Graham
Depth Chart:
QB: Jimmy Garoppolo
Brian Hoyer, Aidan O’Connell (R), Chase Garbers
RB: Josh Jacobs
Ameer Abdullah, Brandon Bolden, Zamir White, Sincere McCormick, Brittain Brown, Austin Walter
FB: Jakob Johnson
WR: Davante Adams, Jakobi Meyers, Hunter Renfrow
DeAndre Carter, Phillip Dorsett, Keelan Cole Sr., Tre Tucker (R), Tyler Johnson, Cam Sims, DJ Turner, Chris Lacy
TE: Austin Hooper, Michael Mayer (R)
OJ Howard, Jesper Horsted, Cole Fotheringham, John Samuel Shenker (R)
Projections: updated 8/28/23
| Player | Pos. | Comp. | PaAtt | % | PaYards | Ypa. | PaTDs | INTs | RuAtt | RuYards | Ypc. | RuTDs |
| Jimmy Garoppolo | QB | 325 | 495 | 65.66% | 3,570 | 7.21 | 21 | 8 | 35 | 55 | 1.57 | 1 |
| Brian Hoyer | QB | 35 | 60 | 58.33% | 415 | 6.92 | 2 | 2 | 5 | 5 | 1.00 | |
| Aidan O’Connell | QB | 30 | 50 | 60.00% | 340 | 6.80 | 2 | 2 |
| Player | Pos. | RuAtt | RuYards | Ypc. | RuTDs | Fmb. | Rec | Targets | RecYards | Ypc. | RecTDs |
| Josh Jacobs | RB | 295 | 1,345 | 4.56 | 10 | 1 | 44 | 55 | 310 | 7.05 | 1 |
| Zamir White | RB | 75 | 335 | 4.47 | 3 | 10 | 15 | 70 | 7.00 | ||
| Brandon Bolden | RB | 15 | 55 | 3.67 | 3 | 5 | 25 | 8.33 | |||
| Ameer Abdulah | RB | 5 | 15 | 3.00 | 15 | 20 | 105 | 7.00 | 1 | ||
| Jakob Johnson | RB | 3 | 5 | 15 | 5.00 | ||||||
| RB6 | RB | ||||||||||
| Davante Adams | WR | 100 | 165 | 1,230 | 12.30 | 8 | |||||
| Jakobi Meyers | WR | 4 | 25 | 6.25 | 69 | 100 | 785 | 11.38 | 4 | ||
| Hunter Renfrow | WR | 4 | 20 | 5.00 | 59 | 85 | 645 | 10.93 | 4 | ||
| Keelan Cole | WR | 17 | 30 | 215 | 12.65 | 1 | |||||
| Phillip Dorsett | WR | 11 | 18 | 145 | 13.18 | ||||||
| Tre Tucker | WR | 5 | 8 | 80 | 16.00 | ||||||
| DeAndre Carter | WR | 3 | 5 | 35 | 11.67 | ||||||
| Michael Mayer | TE | 39 | 59 | 445 | 11.41 | 4 | |||||
| Austin Hooper | TE | 16 | 25 | 165 | 10.31 | 1 | |||||
| Jesper Horsted | TE | 3 | 5 | 30 | 10.00 | 1 | |||||
| TE4 | TE | 3 | 5 | 25 | 8.33 |
2023 Draft Class:
| Pick | Ovr. | Pos. | Player | School |
| 1.07 | 7 | EDGE | Tyree Wilson | Texas Tech |
| 2.04 | 35 | TE | Michael Mayer | Notre Dame |
| 3.07 | 70 | DT | Byron Young | Alabama |
| 3.37 | 100 | WR | Tre Tucker | Cincinnati |
| 4.02 | 104 | CB | Jakorian Bennett | Maryland |
| 4.33 | 135 | QB | Aidan O’Connell | Purdue |
| 5.35 | 170 | S | Christopher Smith II | Georgia |
| 6.26 | 203 | LB | Amari Burney | Florida |
| 7.14 | 231 | DT | Nesta Jade Silvera | Arizona State |
2022 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 3.26 | 90 | OG | Dylan Parham | LV | Memphis |
| 4.17 | 122 | RB | Zamir White | LV | Georgia |
| 4.21 | 126 | DT | Neil Farrell Jr. | LV | LSU |
| 5.32 | 175 | DT | Matthew Butler | LV | Tennessee |
| 7.29 | 250 | RB | Brittain Brown | LV | UCLA |
2021 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.17 | 17 | OT3 | Alex Leatherwood | LV | Alabama |
| 2.11 | 43 | S3 | Trevon Moehrig | LV | TCU |
| 3.15 | 79 | DE11 | Malcolm Koonce | LV | Buffalo |
| 3.16 | 80 | S5 | Divine Deablo | LV | Virginia Tech |
| 4.38 | 143 | S6 | Tyree Gillespie | LV | Missouri |
| 5.23 | 167 | CB25 | Nate Hobbs | LV | Illinois |
| 7.02 | 230 | C7 | Jimmy Morrissey | LV | Pittsburgh |
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 1.12 | 12 | WR | Henry Ruggs III | Alabama |
| 1.19 | 19 | CB | Damon Arnette | Ohio State |
| 3.16 | 80 | RB | Lynn Bowden | Kentucky |
| 3.17 | 81 | WR | Bryan Edwards | South Carolina |
| 3.36 | 100 | S | Tanner Muse | Clemson |
| 4.03 | 109 | G | John Simpson | Clemson |
| 4.33 | 139 | CB | Amik Robertson | Louisiana Tech |