HC: Lovie Smith
OC: Pep Hamilton
DC: Lovie Smith
Depth Chart:
QB: Davis Mills
Jeff Driskel, Kyle Allen, Kevin Hogan
RB: Marlon Mack, Rex Burkhead
Dameon Pierce (R), Dare Ogunbowale, Royce Freeman, Darius Anderson
FB: Andy Janovich
Paul Quessenberry
WR: Brandin Cooks, Nico Collins, John Metchie III (R)
Chris Conley, Phillip Dorsett, Chris Moore, Davion Davis, Damon Hazelton, DaeSean Hamilton, Jalen Camp, Johnny Johnson III (R), Andrew Estrada (R)
TE: Pharaoh Brown, Brevin Jordan
Teagan Quitoriano (R), Antony Auclair, Seth Green (R)
2022 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.03 | 3 | CB | Derek Stingley Jr. | HOU | LSU |
| 1.15 | 15 | OG | Kenyon Green | HOU | Texas A&M |
| 2.05 | 37 | S | Jalen Pitre | HOU | Baylor |
| 2.12 | 44 | WR | John Metchie III | HOU | Alabama |
| 3.11 | 75 | LB | Christian Harris | HOU | Alabama |
| 4.02 | 107 | RB | Dameon Pierce | HOU | Florida |
| 5.07 | 150 | DT | Thomas Booker | HOU | Stanford |
| 5.27 | 170 | TE | Teagan Quitoriano | HOU | Oregon State |
| 6.26 | 205 | OT | Austin Deculus | HOU | LSU |
2021 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 3.03 | 67 | QB8 | Davis Mills | HOU | Stanford |
| 3.25 | 89 | WR14 | Nico Collins | HOU | Michigan |
| 5.03 | 147 | TE9 | Brevin Jordan | HOU | Miami |
| 5.26 | 170 | LB15 | Garret Wallow | HOU | TCU |
| 6.11 | 195 | DT15 | Roy Lopez | HOU | Arizona |
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 2.08 | 40 | DT | Ross Blacklock | TCU |
| 3.26 | 90 | EDGE | Jonathan Greenard | Florida |
| 4.20 | 126 | T | Charlie Heck | North Carolina |
| 4.35 | 141 | CB | John Reid | Penn State |
| 5.26 | 171 | WR | Isaiah Coulter | Rhode Island |