HC: Dan Campbell
OC: Ben Johnson
DC: Aaron Glenn
Depth Chart:
QB: Jared Goff
Tim Boyle, David Blough, Steven Montez
RB: D’Andre Swift
Jamaal Williams, Craig Reynolds, Jermar Jefferson, Godwin Igwebuike, Greg Bell (R)
FB: Jason Cabinda
WR: Amon-Ra St. Brown, DJ Chark, Jameson Williams
Josh Reynolds, Quintez Cephus, Kalif Raymond, Trinity Benson, Javon McKinley, Tom Kennedy, Corey Sutton (R), Josh Johnson (R), Kalil Pimpleton (R)
TE: TJ Hockenson
Garrett Griffin, Brock Wright, Jared Pinkney, Matt Sokol, Shane Zylstra, James Mitchell (R), Derrick Deese Jr. (R), Nolan Givan (R)
2022 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.02 | 2 | DE | Aidan Hutchinson | DET | Michigan |
| 1.12 | 12 | WR | Jameson Williams | DET | Alabama |
| 2.14 | 46 | EDGE | Josh Paschal | DET | Kentucky |
| 3.33 | 97 | S | Kerby Joseph | DET | Illinois |
| 5.34 | 177 | TE | James Mitchell | DET | Virginia Tech |
| 6.09 | 188 | LB | Malcolm Rodriguez | DET | Oklahoma State |
| 6.38 | 217 | LB | James Houston IV | DET | Jackson State |
| 7.16 | 237 | CB | Chase Lucas | DET | Arizona State |
2021 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.07 | 7 | OT1 | Penei Sewell | DET | Oregon |
| 2.09 | 41 | DT2 | Levi Onwuzurike | DET | Washington |
| 3.08 | 72 | DT3 | Alim McNeill | DET | NC State |
| 3.37 | 101 | CB14 | Ifeatu Melifonwu | DET | Syracuse |
| 4.07 | 112 | WR17 | Amon-Ra St. Brown | DET | USC |
| 4.08 | 113 | LB11 | Derrick Barnes | DET | Purdue |
| 7.29 | 257 | RB18 | Jermar Jefferson | DET | Oregon State |
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 1.03 | 3 | CB | Jeff Okudah | Ohio State |
| 2.03 | 35 | RB | D’Andre Swift | Georgia |
| 3.03 | 67 | EDGE | Julian Okwara | Notre Dame |
| 3.11 | 75 | G | Jonah Jackson | Oho State |
| 4.15 | 121 | G | Logan Stenberg | Kentucky |
| 5.21 | 166 | WR | Quintez Cephus | Wisconsin |
| 5.27 | 172 | RB | Jason Huntley | New Mexico State |
| 6.18 | 197 | DT | John Penisini | Utah |
| 7.21 | 23 | DT | Jashon Cornell | Ohio State |