HC: Vic Fangio
OC: Pat Shurmur
DC: Ed Donatell
Depth Chart: (blue = drafted, green = udfa)
QBs: Drew Lock
Teddy Bridgewater – Brett Rypien
RBs: Melvin Gordon – Javonte Williams (2nd)
Mike Boone – Royce Freeman – LeVante Bellamy – Damarea Crockett
FB: Andrew Beck
Adam Prentice
WRs: Courtland Sutton – Jerry Jeudy – KJ Hamler – Tim Patrick
Seth Williams (6th) – Tyrie Cleveland – Diontae Spencer – Kendall Hinton – Trinity Benson – Isaiah Mack – Branden Mack – DeVontres Dukes – Warren Jackson
TEs: Noah Fant
Albert Okwuegbunam – Troy Fumagalli – Austin Fort – Eric Saubert – Shaun Beyer
2021 Draft Class:
| Pick | Overall | Pos. | Player | College |
| 1.09 | 9 | CB2 | Patrick Surtain II | Alabama |
| 2.03 | 35 | RB3 | Javonte Williams | UNC |
| 3.34 | 98 | C4 | Quinn Meinerz | UW Whitewater |
| 3.41 | 105 | LB10 | Baron Browning | Ohio State |
| 5.08 | 152 | S8 | Caden Sterns | Texas |
| 5.20 | 164 | S11 | Jamar Johnson | Indiana |
| 6.35 | 219 | WR30 | Seth Williams | Auburn |
| 7.09 | 237 | CB36 | Kary Vincent Jr. | LSU |
| 7.11 | 239 | DE31 | Jonathan Cooper | Ohio State |
| 7.25 | 253 | DE34 | Marquiss Spencer | Mississippi State |
2021 Notable Offseason Additions:
- QB Teddy Bridgeater (trade)
- RB Mike Boone
- CB Ronald Darby
- CB Kyle Fuller
2021 Notable Offseason Departures:
- CB AJ Bouye
- DE Jurrell Casey
- TE Nick Vannett
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 1.15 | 15 | WR | Jerry Jeudy | Alabama |
| 2.14 | 46 | WR | KJ Hamler | Penn State |
| 3.13 | 77 | CB | Michael Ojemudia | Iowa |
| 3.19 | 83 | CB | Lloyd Cushenberry | LSU |
| 3.31 | 95 | DT | McTelvin Agim | Arkansas |
| 4.12 | 118 | TE | Albert Okwuegbunam | Missouri |
| 5.33 | 178 | LB | Justin Strnad | Wake Forest |
| 6.02 | 181 | G | Netane Muti | Fresno State |
| 7.38 | 252 | WR | Tyrie Cleveland | Florida |
| 7.40 | 254 | EDGE | Derrek Tuszka | NDSU |
Helpful Links:
Total Offensive Plays Per Game
Total Offensive Plays Per Season (filter by Ply)