HC: Sean McDermott
OC: Ken Dorsey
DC: Leslie Frazier
Depth Chart:
QB: Josh Allen
Case Keenum, Matt Barkley
RB: Devin Singletary
James Cook (R), Duke Johnson, Zack Moss, Taiwan Jones, Raheem Blackshear (R)
FB: Reggie Gilliam
WR: Stefon Diggs, Gabriel Davis, Jamison Crowder
Isaiah McKenzie, Khalil Shakir (R), Jake Kumerow, Marquez Stevenson, Isaiah Hodgins, Tanner Gentry, Neil Pau’u (R), Malik Williams (R)
TE: Dawson Knox
OJ Howard, Tommy Sweeney, Quintin Morris, Jalen Wydermyer (R)
Redraft Take: We’re taking Josh Allen as the QB1 off the board this year, and Stefon Diggs remains a top 5 WR threat. I’m very unsure on how the RB touches shake out. Singletary balled out late last year, but adding James Cook and Duke Johnson makes me question his receiving work load. And Zack Moss still lingers. I think I’ll stay away from this backfield. People are very high on Gabriel Davis this year, maybe too high for my liking, as he costs a 6th Round pick minimum. I’m more interested in Jamison Crowder at ADP, as the Bills slot WR has been the 2nd leading WR on this team for the past 3/4 years. Dawson Knox is a preferred TE target for me in the 9th round. With Crowder’s injury history keep an eye on Isaiah McKenzie and Khalil Shakir.
2022 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.23 | 23 | CB | Kaiir Elam | BUF | Florida |
| 2.31 | 63 | RB | James Cook | BUF | Georgia |
| 3.25 | 89 | LB | Terrel Bernard | BUF | Baylor |
| 5.05 | 148 | WR | Khalil Shakir | BUF | Boise State |
| 6.01 | 180 | P | Matt Araiza | BUF | San Diego State |
| 6.06 | 185 | CB | Christian Benford | BUF | Villanova |
| 6.30 | 209 | OT | Luke Tenuta | BUF | Virginia Tech |
| 7.10 | 231 | LB | Baylon Spector | BUF | Clemson |
2021 Draft Class:
| Pick | Overall | Pos. | Player | College |
| 1.30 | 30 | DE4 | Greg Rousseau | Miami |
| 2.29 | 61 | DE9 | Boogie Basham | Wake Forest |
| 3.29 | 93 | OT12 | Spencer Brown | Northern Iowa |
| 5.17 | 161 | OT20 | Tommy Doyle | Miami OH |
| 6.19 | 203 | WR25 | Marquez Stevenson | Houston |
| 6.28 | 212 | S17 | Damar Hamlin | Pittsburgh |
| 6.29 | 213 | CB32 | Rachad Wildgoose | Wisconsin |
| 7.08 | 236 | OG12 | Jack Anderson | Texas Tech |
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 2.22 | 54 | DE | AJ Epenesa | Iowa |
| 3.22 | 86 | RB | Zack Moss | Utah |
| 4.22 | 128 | WR | Gabriel Davis | UCF |
| 5.22 | 167 | QB | Jake Fromm | Georgia |
| 6.09 | 188 | K | Tyler Bass | Georgia Southern |
| 6.28 | 207 | WR | Isaiah Hodgins | Oregon State |
| 7.25 | 239 | CB | Dane Jackson | Pittsburgh |