HC: Sean McDermott
OC: Ken Dorsey
DC: Leslie Frazier
Depth Chart:
QB: Josh Allen
Case Keenum, Matt Barkley
RB: Devin Singletary
James Cook (R), Duke Johnson, Zack Moss, Taiwan Jones, Raheem Blackshear (R)
FB: Reggie Gilliam
WR: Stefon Diggs, Gabriel Davis, Jamison Crowder
Isaiah McKenzie, Khalil Shakir (R), Jake Kumerow, Marquez Stevenson, Isaiah Hodgins, Tanner Gentry, Neil Pau’u (R), Malik Williams (R)
TE: Dawson Knox
OJ Howard, Tommy Sweeney, Quintin Morris, Jalen Wydermyer (R)
2022 Draft Class:
| Pick | Overall | Pos. | Player | Team | College |
| 1.23 | 23 | CB | Kaiir Elam | BUF | Florida |
| 2.31 | 63 | RB | James Cook | BUF | Georgia |
| 3.25 | 89 | LB | Terrel Bernard | BUF | Baylor |
| 5.05 | 148 | WR | Khalil Shakir | BUF | Boise State |
| 6.01 | 180 | P | Matt Araiza | BUF | San Diego State |
| 6.06 | 185 | CB | Christian Benford | BUF | Villanova |
| 6.30 | 209 | OT | Luke Tenuta | BUF | Virginia Tech |
| 7.10 | 231 | LB | Baylon Spector | BUF | Clemson |
2021 Draft Class:
| Pick | Overall | Pos. | Player | College |
| 1.30 | 30 | DE4 | Greg Rousseau | Miami |
| 2.29 | 61 | DE9 | Boogie Basham | Wake Forest |
| 3.29 | 93 | OT12 | Spencer Brown | Northern Iowa |
| 5.17 | 161 | OT20 | Tommy Doyle | Miami OH |
| 6.19 | 203 | WR25 | Marquez Stevenson | Houston |
| 6.28 | 212 | S17 | Damar Hamlin | Pittsburgh |
| 6.29 | 213 | CB32 | Rachad Wildgoose | Wisconsin |
| 7.08 | 236 | OG12 | Jack Anderson | Texas Tech |
2020 Draft Class:
| Pick | Overall | Position | Player | College |
| 2.22 | 54 | DE | AJ Epenesa | Iowa |
| 3.22 | 86 | RB | Zack Moss | Utah |
| 4.22 | 128 | WR | Gabriel Davis | UCF |
| 5.22 | 167 | QB | Jake Fromm | Georgia |
| 6.09 | 188 | K | Tyler Bass | Georgia Southern |
| 6.28 | 207 | WR | Isaiah Hodgins | Oregon State |
| 7.25 | 239 | CB | Dane Jackson | Pittsburgh |