updated 1/16/23
| Rank | Running Back | Team | Note |
| 1 | Jonathan Taylor | IND | prime |
| 2 | Breece Hall | NYJ | prime/injury recovery |
| 3 | Kenneth Walker | SEA | prime |
| 4 | Christian McCaffrey | SF | prime vet |
| 5 | Saquon Barkley | NYG | prime vet |
| 6 | Travis Etienne | JAX | prime |
| 7 | Javonte Williams | DEN | prime/injury recovery |
| 8 | Josh Jacobs | LV | prime vet |
| 9 | Tony Pollard | DAL | prime |
| 10 | D’Andre Swift | DET | prime |
| 11 | Rhamondre Stevenson | NE | prime |
| 12 | Najee Harris | PIT | prime |
| 13 | Austin Ekeler | LAC | prime vet |
| 14 | Nick Chubb | CLE | prime vet |
| 15 | Joe Mixon | CIN | prime vet |
| 16 | James Cook | BUF | prime |
| 17 | Dameon Pierce | HOU | prime |
| 18 | JK Dobbins | BAL | prime |
| 19 | Miles Sanders | PHI | prime vet |
| 20 | Derrick Henry | TEN | back 9 |
| 21 | Alvin Kamara | NO | prime vet |
| 22 | Aaron Jones | GB | prime vet |
| 23 | Dalvin Cook | MIN | prime vet |
| 24 | Rachaad White | TB | prime |
| 25 | Cam Akers | LAR | prime |
| 26 | AJ Dillon | GB | prime RB2 |
| 27 | Brian Robinson | WAS | prime RB2 |
| 28 | Devin Singletary | BUF | prime RB2 |
| 29 | Antonio Gibson | WAS | prime RB2 |
| 30 | David Montgomery | CHI | prime RB2 |
| 31 | Kareem Hunt | CLE | back 9 |
| 32 | Khalil Herbert | CHI | prime |
| 33 | Isiah Pacheco | KC | unknown upside |
| 34 | Tyler Allgeier | ATL | unknown upside |
| 35 | Ezekiel Elliott | DAL | back 9 |
| 36 | Alexander Mattison | MIN | journeyman |
| 37 | Damien Harris | NE | prime RB2 |
| 38 | Leonard Fournette | TB | back 9 |
| 39 | D’Onta Foreman | CAR | journeyman |
| 40 | James Conner | ARI | back 9 |